<I>Stimulation of O<SUP>-</SUP><SUB>2</SUB>-release from phagocytes by bacterial cell-wall components</I>
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概要
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Muramyl dipeptide (MDP) and lipopolysaccharide (LPS) from <I>E. coli</I> were tested for their ability to influence superoxide anion (O<SUP>-</SUP><SUB>2</SUB>) release from phagocytes of guinea pigs. Both MDP and LPS alone did not, by themselves stimulate macrophages and polymorphonuclear leukocytes (PMN) to release O<SUP>-</SUP><SUB>2</SUB>. However, the preincubation of macrophages with MDP or LPS primed the macrophages to release the enhanced amount of O<SUP>-</SUP><SUB>2</SUB> when stimulated by cytochalasin E (Cyt E) and wheat germ agglutinin (WGA) . When PMN were treated in the same way, only LPS showed an enhancing effect. MDP enhanced NADPH oxidase activity of macrophages, which is probably the reason for the enhanced O<SUP>-</SUP><SUB>2</SUB> release by MDP.
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