<I>Chemotactic factors associated with macrophage reaction in immune tissue injuries of their functional specifity</I>

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We separated three macrophage (Mφ) chemotactic factors (MCF-a, -b, and -c) from DNP-ascaris extract-induced and PPD-induced hypersensitivity reaction sites in guinea pigs and highly purified them. MCF-a (mw 150, 000) was generated from serum IgG molecule by neutrophil neutral elastase-like enzyme (mw 27, 000) and -b (mw 14, 000) from C5 molecule by neurophil neutral chymotrypsinlike enzyme (mw 35, 000), and -c (mw 110, 000) was found to exist as a complex of Mφ chemotactic lymphokine (mw 12, 500) and serum α-globulin exuded at the reaction sites. These chemotactic factors were characteristically associated with development of Mφ reactions in the immune tissue injuries. Their Mφ chemotactic activities were confirmed to be trans-species specific. MCF-a and -b were effective for la-negative Mφ of guinea pig and mouse, while MCF-c was active for Ia-positive Mφ of the animals. Thus, further functional analysis of the Mφ was strongly required for fundamental understanding of the immune tissue injuries.
日本炎症・再生医学会の論文