Immune modulation with hsp 65 of Mycobacterium leprae. Type 1/Type 2 cytokine production in NOD mice.

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Immune modulation in NOD mice was evaluated using hsp 65 of <I>Mycobacterium leprae.</I><BR>The splenocyte cultures of NOD mice isolated from 6 weeks of age, which shows no or weak insulitis, produced no IFN-γ without hsp 65 stimulation, but produced with hsp 65 stimulation. On the contrary, the splenocyte cultures isolated from 14 weeks, 21 weeks and 28 weeks, which developed heavy insulitis or IDDM, produced high titer of IFN-γ, and if stimulated with hsp 65, the IFN-γ production have been inhibited by producing IL-10. Thus, hsp 65 had a diversity role in immune responses for IFN-γ production. One is inducing role for IFN-γ and another is inducing role for IL-10.<BR>On IL-12 production, the splenocyte cultures isolated from any ages of NOD mice produced IL-12 physiologically, and hsp 65 stimulation inhibited the IL 12 production completely by inducing IL-10.
日本炎症・再生医学会の論文