<I>Effects of CCA (Disodium 4-chloro-2, 2'-iminodibenzoate) on the biological activities of both lymphocytes and macrophages were investigated</I>
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In the <I>in vitro</I> studies of murine lymphocytes, CCA showed a tendency to increase the viability of spleen cells and an activity to enhance the mitogenic responses of those cells by LPS, B-mitogen. Enhancing effects of CCA on T-mitogen-induced lymphocytes reaction have also been reported in other papers. These results were considered in connection with a phenomenon that CCA increased the RNA polymerase activity of nucleus from rat lymphnode cells. CCA also enhanced the<I>in vivo </I>mitogenic reaction by Con A. CCA was not mytogenic by itself.<BR>As for the activities of macrophages, CCA did not almost show any effects in<I>in vitro</I>studies while it did in the carbon clearance test using both normal and tumor-bearing animals.
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