Relationship between occurrence of late asthmatic response(LAR) and eosinophilia in peripheral blood and lung tissue.

概要

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It is well known that eosinophils increase in peripheral blood, sputum and lung tissues of patients suffering from bronchial asthma. Because eosinophil contains various cytotoxic proteins in the granule, and has abilities to produce bronchoconstrictive mediators such as peptide-leukotrienes, it has been suggested that the leukocyte involves in the occurrence of LAR as well as bronchial hyperresponsiveness, characteristic features of the disease in a serious case. In our basic experiments <I>in vivo</I> using a guinea pig asthmatic model, occurrence of LAR, and considerable increases of eosinophil number in the peripheral blood and the bronchoalveoli coincided with each other 5-7 hr after the antigen inhalation challenge. Significant elevation of eosinophil peroxidase activity in the lung homogenate was also observed 5 hr after the challenge. It can be considered that the increased eosinophils in the circulation, which might be recruited by cytokines such as interleukin-5 from the rapidly mobilizable bone marrow pool of eosinophils, infiltrated into the lung tissue. We also describe postulated mechanisms about eosinophil infiltration into tissues, which was recently reported, or obtained in our laboratory.
日本炎症・再生医学会の論文