Gene therapy strategy of glomerulosclerosis.
スポンサーリンク
概要
- 論文の詳細を見る
To analyze human diseases at molecular level and to promote gene therapy strategy, we developed HVJ-liposome gene delivery system. By the transfer of TGF-β gene to rat glomerulus using the system, glomerulosclerotic changes characterized by the accumulation of extracellular matrix were induced in rat kidney. To suppress TGF-β by antisense oligonucleotides in experimental glomerulonephritic rats, glomerulosclerotic changes were inhibited. Therefore, TGF-β appears to be responsible for the pathogenesis of glomerulosclerotic changes. Toward the gene therapy of glomerulosclerosis, decorin gene was introduced into nephritic rat muscle. Decorin was expressed in muscle and accumulated in glomerulus. By decorin gene transfer, TGF-β expression was suppressed in nephritic rat kidney and a number of TGF-β positive glomerulus was reduced to 40% compared with the rat treated with CAT gene. The accumulation of extracellular matrix proteins was decreased. These results indicate that decorin gene transfer to muscle will be promising for gene therauv of glomerulosclerosis.
- 日本炎症・再生医学会の論文
日本炎症・再生医学会 | 論文
- 新規キノリノン誘導体TA-270の炎症性気道疾患に対する効果
- Salazosulphapyridine, Predonizolone の好中球機能に及ぼす影響と Sodium ferrous citrate との併用効果についての検討
- Sodium ferrous citrate の好中球機能に及ぼす影響
- Mesalazine(Pentasa) の好中球機能に及ぼす影響と Sodium ferrous citrate(SFC) との併用効果についての検討
- 非ウイルスベクターによる細胞標的法の開発