Effects of Acteoside (TJC-160) on alteration of adhesion molecules in glomeruli of crescentic-type anti-GBM nephritic rats.

概要

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In order to clarify the antinephritic mechanisms of acteoside (TJC-160), a component of Stachys sieboldii MIQ (Chorogi), the effects of TJC-160 on adhesion molecule were evaluated with crescentic-type anti-GBM nephritic rats. TJC-160 was administered orally, once a day from the day after the injection of anti-GBM serum and continued througout the experiment. TJC-160 improved proteinuria during the experimental period. The number of LEA-1 positive cells or ICAM-1 expression in glomeruli of nephritic rats increased by day 20 or day 25, respectively. In addition, the number of ED 1, CD8, RT 7.2 (granulocytes) and Ia positive cells in glomeruli of nephritic rats was elevated by the 15th day, and then restored to the normal level by the 35th days. TJC-160 markedly prevented the increased number of LFA-1 and the expression of ICAM-1 in glomeruli. Moreover, TJC-160 suppressed the increase in the number of ED-1, CD8 and Ia positive cells by 40-60%. TJC-160, however, failed to suppress the production of specific antibody against rabbit γ globulin. These results indicate that the antinephritic effect of TJC-160 may be at least partly due to the inhibition of glomerular infiltration of certain leukocyte subsets and the expression of adhesion molecules.
日本炎症・再生医学会の論文