Apoptosis of synovia, cartilage and bone in rheumatoid arthritis demonstrated by immunohistochemical study using anti-Ley antigen antibodies.

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Ley antigen expression is assumed to be a predisposing marker for apoptosis. In this study we semi-quantitatively examined apoptosis of cells in joint tissues, such as synovia, cartilage and bone in rheumatoid arthritis (RA) by means of an immuno-histochemical technique with anti-Ley antigen antibodies. In synovia of patients with trauma or osteoarthritis (OA), only a few inflammatory cells were positive for Ley, while in RA, inflammatory cells, mainly neutrophils, were strongly Ley positive. Furthermore capillary endothelial cells were also Ley positive. In RA the number of Ley positive inflammatory cells increased with the progression of inflammation, and decreased with the progression of fibrosis. The number of capillaries with Ley positive endothelial cells, revealed same tendency. We concluded therefore that apoptosis is related to the degree of inflammation in RA. In bone and cartilage of patients with RA, some chondrocytes neighboring granulations were Ley positive, but there were no positive cells in patients with OA. For this reason we propose that apoptosis of chondrocytes may be triggering to cartilagenous destruction as well as production of proteinases in RA.
日本炎症・再生医学会の論文