Significacne of H. pylori in fections inchronic gastritis from the morphological viewpoint.

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Correlations between the amounts of<I>H.pylori</I> (HP) or the titers of anti-HP Ab in the sera of the patients with chronic gastritis and neutrophil infiltration in the gastric specimens were studied. HP was detected in 57% (24/42) of the patients with chronic gastritis. Neutrophil infiltration in lamina propria, epithelial cell layer and mucous layer were abundant according to the amount of HP in the gastric specimens (P<0.01) . In the HP (+) group by culture, titers of anti-HP Ab of sera were higher than in HP (-) group (P<0.02) .<BR>By the ultrastructural studies, 60% of HP were floating in the mucous layer. On the other hand, 30% of HP attached to the gastric epithelial cells. In cases HP were observed frequently, vacuolar degeneration of the epithelial cells and loosening of tight junctions or bacterial invasion in the cells were common.<BR>In conclusion, direct influences of HP to the gastric epithelial cells or their environment such as neutrophil infiltration was detected in the HP (+) chronic gastritis.
日本炎症・再生医学会の論文