Influence of neutrophil elastase on experimental rheumatoid arthritis.

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To elucidate the role of neutrophil elatsase on joint destruction in rheumatoid arthritis (RA), the following experiments were performed.<BR>1. A specific inhibitor of neutrophil elastase (ONO-5046) was injected into the knee joint three times a week for three weeks in heat-killed E. coli O: 14 induced arthritis in 10 rabbits, which were prepared as RA models. As a result, the development of pathological changes in the synovial membrane and cartilage was found to be suppressed.<BR>2. Neutrophil elastase dissolved in saline was injected into the knee joint of rabbits for three to nine weeks in order to examine its effect on the joint histologically. A moderate degree of synovitis was observed in all the synovial membranes. In the long-term groups, the cartilage also degenerated.<BR>These findings suggested that neutrophil elastase should play a role as one of the etiologies to the joint destructive process of RA, and that the clinical application of its inhibitors might be expected.
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