Urinary deoxypyridinoline in the development of adjuvant-induced arthritis rats.
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概要
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The present study was undertaken to clarify the changes of bone metabolism of adjuvant-induced arthritis rats (AA) . After adjuvant inoculation to rats, urinary deoxypiridinoline content was gradually increased with developing AA. The third lumbar vertebra (L<SUB>3</SUB>) was used for determination of morphological change on 28 days after adjuvant inoculation. The trabecular bone number of the L<SUB>3</SUB> vertebra significantly decreased in comparison with the control group of the same age. The study has shown that AA has a pronounced effect on vertebral bone mass and quality with collagen destruction.
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