IL-8 expression on rheumatoid arthritis(RA) and osteoarthritis(OA). Analysis by immunohistochemistry and in situ hybridization.:—Analysis by immunohistochemistry and in situ hybridization—

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Interleukin 8 (IL-8) is the inflammatory cytokine that activates neutrophils. Recently, it has been reported activated neutrophils contribute to the cartilage degradation. Previous reports have been suggested interleukin-8 (IL-8) exists in high concentration in RA synovial fluid. In vitro study, various cells such as synoviocytes, monocytes/macrophages, fibroblasts and endothelial cells were reported to produce IL-8. We tried to detect IL-8 producing cells on RA synovial tissues by immunohisto-chemistry and in situ hybridization. In RA synovial tissues, IL-8 products and mRNA were detected on synovial lining cells, fibroblastoid cells, monocytes/macrophages, endothelial cells, and neutrophils. Intensity of IL-8 expression was correlated with the inflammation of synovial tissues. On the other hand, IL-8 scarecely expressed on synovial lining cells and endothelial cells in osteoarthritic synovium. These data suggest IL-8 may play an important role on inflammation and joint destruction in RA synovial tissues.
日本炎症・再生医学会の論文