Platelet-activating factor and cell response.

概要

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Platelet-activating factor (PAF) is not only a potent proinflammatory compound, but also is involved in cell proliferation and differentiation. cDNAs coding for PAF receptor were isolated in our laboratory from human, guinea-pig, rat and mouse. They consist of 341-342 amino acids with 7 putative transmembrane domains, characteristic to a G-protein-coupled-receptor superfamily. The gene for human PAF receptor is localized on chromosome 1, having three exons separated each other. By 5'-alternative splicing, two transcripts (leukocyte- and heart-type) are expressed under the direction of two distinct promoters. Signal transduction of PAF receptor disclosed that it couples with multiple effector systems including phospholipase C activation, inhibition of adenylate cyclase, MAP kinase activation, and phospholipase A<SUB>2</SUB> activation. These multiple second messenger systems enable the versatile biological activities of PAF, in spite that PAF is a single molecule without any receptor subtypes.
日本炎症・再生医学会の論文