Acute phase reactant in urine: Urinary trypsin inhibitor in cases of children's infectious diseases.

概要

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Urinary trypsin inhibitor (UTI) is a glycoprotein which is excreted in human urine, and an inhibitor to multiple enzymes. In recent years, UTI has been recognized to be one of acute phase reactants in cases of infection and so on, because the amount of UTI excreted in urine increases or decreases in concentration in parallel with those of serum CRP and/or erythrocyte sedimentation rate, etc. However, study on UTI so far in the area of pediatrics is rare, so, we examined in 66 cases of children suffering from infection.<BR>In this report, 13.6% of false negative cases were observed with respect to CRP. The amount of UTI was found to increase in the early days as serum CRP, and UTI moved to decrease in parallel with that of CRP when the diseases became getting well. Moreover, the ratio of UTI values between admission and discharge was proved almost equal to that of CRP.<BR>The results suggested the immunological assay of UTI is sensitive and useful to detect and monitor the course of infections as well as CRP. Because of less invasive method, that is, urine is sample, routine assay of UTI would be desired.
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