Preparation of an animal model of chronic pseudo-infection in lower respiratory tracts and effect of erythromycin.

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The possibility has been proposed that the vicious cycle which consists of basal diseases, bacterial metabolites and host persistent inflammation affected on intractability of chronic respiratory tract infections (CRTI) . To elucidate the contribution of host inflammation to the intractability of CRTI, we investigated the effect of repeated inhalations of sterilized <I>Escherichia coli</I>suspension on cellular and biochemical parameters in bronchoalveolar lavage fluid (BALF) and lung tissue using rats. An influx of neutrophils, a leakage of albumin and an increase of neutrophil elastase activity in airways were maintained during the repeated inhalations, which confirmed that there arose a chronic pulmonary inflammation. In histological studies, the lung tissue of inhaled rats showed chronic inflammatory features which resembled in diffuse panbronchiolitis. In the model, erythromycin reduced the number of neutrophils, the concentration of albumin, and the elastase activity in BALF. Furthermore, no or weak histological changes were observed in the lung tissue of rats treated with erythromycin, and the deterioration of pulmonary mechanics was suppressed.<BR>These results suggest that host persistent and excessive inflammation contributes markedly to the exacerbation of basal disease caused by CRTI, and that the suppression of such inflammation is promising to its medical care.
日本炎症・再生医学会の論文