Anti-inflammatory effects of TSA-234 (recombinant human superoxide dismutase).
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Anti-inflammatory effects of TSA-234 (recombinant human superoxide dismutase, rhSOD) were studied <I>in vitro</I>and <I>in vivo</I>. TSA-234, 0.1-100 μg/ ml, significantly inhibited damage of chondrocytes, reduction inviscosity of hyaluronic acid and osteoarthrosis-derived joint fluid, delayed gelation of collagen and inactivation of α<SUB>1</SUB>-proteinase inhibitor (PI) which were induced by active oxygen species generated in the system of hypoxanthine-xanthine oxidase. Intraarticular injection of TSA-234 significantly inhibited both carrageenin-induced arthritis in rabbit knees and sodium urate-induced arthritis in dog knees. Furthermore, TSA-234 significantly inhibited rat carrageenin-induced paw edema and mouse ischemic paw edema by 0.125-1 mg/kg, i. v. and 1 mg/kg, i. v., respectively.<BR>These results suggest that TSA-234 will be useful with an Intraarticular injection on the therapy of osteoarthrosis in knees.
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