<I>Effects of lecithinized superoxide dismutase (PC-SOD) on respiratory resistance induced by Forssman antiserum in guinea pigs</I>
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概要
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We synthesized lecthinized superoxide dismutase (PC-SOD), recombinant human SOD covalently bound to a lecithin derivative. Next, we studied the pharmacological effect of PC-SOD and the mechanism of that.<BR>PC-SOD inhibited the Forssman antiserum-induced respiratory resistance which is known to induce via actions of O<SUB>2</SUB>- at a dose of 100-1, 000 U/kg, whereas unmodified SOD did not.<BR>PC-SOD was more effective at 2.8 fold in inhibiting the superoxide generation of neutrophils than unmodified SOD. Superoxide generation of neutrophils washed after incubation with PC-SOD for 1 hr was inhibited but not with unmodified SOD.<BR>These data suggest that PC-SOD protects lung injury by Forssman antiserum in guinea pigs by binding to neutrophils. PC-SOD would be expected as a useful drug delivery system preparation for SOD.
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