Pharmacologic effect of topical cyclosporin A ointment on skin allograft in rats.

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In this study, we investigated the pharmacologic effect of topical cyclosporin A (CSA) cintment on skin allograft from Lewis rats to Fischer rats. The 10% CSA ointment was prepared and applicated. Untreated allografts were rejected in 11.0±1.0 days, but long term graft survival (26.3±2.7 days) was significantly seen with continuous topical 10% CSA ointment treatment for 12 days at 15 mg/rat/ day (P<0.001) . The mean survival time of allograft receiving topical 10% CSA ointment was significantly (P<0.05) even longer than the allografts receiving 4 mg/kg/day i.v. for 15 days (21.7±4.4 days) .<BR>Light microscopy revealed the deposition of PAS positive granules in and exfoliation of proximal tubular epithelium in rats receiving topical CSA ointment. These changes were observed likewise in untreated rats. So it may be not characteristic of CSA nephrotoxicity.<BR>These results suggest that topical CSA ointment may play an important role in application of allcgraft to cover skin defects caused by severe burn injury.
日本炎症・再生医学会の論文