The effects of non-steroidal anti-inflammatory drugs on prostaglandin E2 and leukotriene B4 activities in synovial fluid in osteoarthritis; Especially the effects of dual inhibitor.
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概要
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The inhibitory influences of indomethacin (IND) and proglumetacin maleate (PGM) on prostaglandin E<SUB>2</SUB> (PGE<SUB>2</SUB>) and leukotriene B<SUB>4</SUB> (LTB<SUB>4</SUB>) activities in synovial fluid in osteoarthritis (OA) were investigated. Clinically, no significant difference was observed in final global improvement rate between IND and PGM groups. PGM group showed an improvement higher than IND group in joint effusion. IND showed selective inhibition of PGE<SUB>2</SUB> formation, but caused a increase in LTB<SUB>4</SUB> formation. On the other hand, PGM showed a almost same inhibitory effects both on PGE<SUB>2</SUB> and LTB<SUB>4</SUB> formation.<BR>These results indicated that PGM, so called dual inhibitor, had a dual inhibitory effects on cyclooxy-genase and lipoxygenase <I>in vivo</I>.
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