Suppressive effect of subminimal inhibitory concentrations of clindamycin on the neutrophil chemotactic factors production in Propionibacterium acnes and coagulase-negative staphylococci.

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The effect of clindamycin (CLDM) at subminimal inhibitory concentrations (sub-MIC), i.e. one-tenth MIC, on the production of human neutrophil chemotactic factors in comedonal bacteria, <I>Propionibacte-rium acnes (P. acnes) </I> strains and coagulase-negative staphylococci (CNS) strains, was assayed using Boyden chamber method. Sub-MIC of CLDM markedly inhibited the production of neutrophil chemotactic factors in all strains of <I>P. acnes</I> and CNS. Our results seem to suggest that sub-MIC of CLDM has an anti-inflammatory effect presumably due to the inhibition of neutrophil chemotactic factors production in comedonal bacteria on the inflammatory process of acne.
日本炎症・再生医学会の論文