The role of CD8 positive lymphocytes in glomerular injury and crescent formation.
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概要
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Masugi nephritis in WKY rats was compared with this nephritis in other strains. WKY rats developed severe proliferative glomerulonephritis with massive proteinuria and crescent formation when a small dose of anti-GBM sera was given. Immunohistochemical examination showed that rabbit IgG, but not rat IgG and C3, was stained in a glomerular capillary walls with a linear pattern, and that the infiltration of CD 8 positive cells preceeded the influx of monocytes/macrophages and crescent formation.<BR>These data indicate that CD 8 positive cells play a key role in the accumulation of monocytes/rnacrophages and urinary protein excretion, and subsequent crescent formation.
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