Thrombin in synovial fluids with osteoarthritis patients.
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概要
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Thrombin activity was investigated in the synovial fluids (SF) obtained from the patients with osteo-arthritis, by measuring prothrombin (pro-Th), antithrombin III (ATIII) and thrombin-AT III complex (TAT) levels. Pro-Th level in the SF was 10% of the plasma levels, while TAT level was one hundred times higher than that in the plasma. These results suggest that, in SF, thrombin was frequently formed and may be concerned with fibrin formation and endothelin release in arthritis.
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