Increased percentage of peripheral blood activated cytotoxic T cell in patients with acute phase fulminant hepatitis.
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概要
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The subsets of peripheral blood lymphocytes in 3 cases with acute type of the fulminant hepatitis (FH) were studied.<BR>The percentage of Leu 2a<SUP>+</SUP>15<SUP>-</SUP> cell and Leu 2a<SUP>+</SUP> HLA-DR<SUP>+</SUP> cell in the peripheral blood at the acute stage increased remarkably in death cases due to FH. In survival cases, increase of Leu 2a<SUP>+</SUP>15<SUP>-</SUP> cell was not noted, while increase of Leu 2a<SUP>+</SUP> HLA-DR<SUP>+</SUP> was noted. The increase of the percentage of these cells was also noted in the acute viral hepatitis type A (AVH), while ratio of Leu 2a<SUP>+</SUP> HLA-DR<SUP>+</SUP> cell/Leo 2a<SUP>+</SUP>15<SUP>-</SUP> cell was higher in FH than in AVH.<BR>These data suggest that activated cytotoxic T lymphocytes may play a role in the pathogenesis of FH.
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