Effect of mizoribine on adjuvant arthritis in rat.
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概要
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The effect of mizoribine (MZR), an immunosuppressive agent on adjuvant arthritis in rats was investigated. The drug was administrated continuously 28 days after immunization with complete adjuvant.<BR>Twice daily p.o doses of 5 or 10 mg/kg of MZR showed a marked inhibition of swelling in hind legs. Moreover mizoribine treatment improved the bone lesion of hind legs. In mizoribine treatment, a decrease of alkaline phosphatase and an increase of serum albumin-globulin ratio was suppressed and the change of wet weight of thymus, spleen, adrenal and liver tissues were inhibited.
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