Arthritis and interleukin 1

概要

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Interleukin 1 (IL-1) is a macrophage derived cytokine that is identified as a thymocyte comitogenic activity. It is now recognized that IL-1 is produced by many cell types and has multiple biological activities on immune and inflammatory reactions. Various cytokines are reported to influence inflammatory reactions either directly or indirectly. However, IL-1 is recognized to be a major inflammatory cytokines with broad spectrum. IL-1 exhibits a number of biological activities on connective tissue cells. IL-1 stimulates rheumatoid synovial cells to produce PGE<SUB>2</SUB>, collagenase, type I collagen and a number of cytokines such as interleukin 6, interleukin 8 and colony stimulating factors. IL-1 also stimulates proliferation of synovial fibroblasts, cartilage degradation and bone resorption. Increased production of IL-1 was reported at the sites of synovitis in patients with rheumatoid arthritis and animal models for arthritis. These findings indicate that IL-1 play an important role in destruction and remodeling of connective tissue in joints.
日本炎症・再生医学会の論文