Synovial membrane and plasma levels of loxoprofen sodium(Loxonin) in RA patients.
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概要
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Loxoprofen sodium was administered to 28 patiens with rheumatoid arthritis who underwent surgical treatment and its concentrations in plasma, synovial membrane, muscle, and fat were studied. OH-derivate is the active metabolite of loxoprofen sodium, and it reached the maximum level in plasma and synovial membrane 2 hours after administration. Thus, a rapid increase of the drug level in the target tissue (synovial membrane) was observed.<BR>The relative concentration ratio of the active metabolite in each tissue 4 hours after administration were as follows: plasma 1.0; synovial membrane 0.93; synovial fluid 0.91; muscle 0.40; and fat 0.09.<BR>These results indicate that selective transfer of loxoprofen sodium into inflamed synoviall membrane and synovial fluid.
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