Opsonic activity of serum, acites fluid, and cerebrospinal fluid in various disease

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Polymorphonuclear leucocytes (PMN) dysfunction, such a that found in chronic granulomatous dise sse, is known to be a contributory factor in severe infections. Because opsonins, in-cluding immunoglobulins and complement, are required for PMN phagocytosis, a dysfunction in opsonins may also lead to severe infections. In this study, the opsonic activity of serum, ascites fluid, or cerebrospinal fluid (CSF) obtained from patients with various disease was examined in an assay employing E. coli (ON 2) and Staph. aureus (502 A) . In a case of congenital dysfunction of complement, diminished opsonic activity was observed against both E. coli and Staph, aureus. In three cases of hypogammaglobulinemia, the activity against E. coli depended upon the amount of IgM in the serum, while activity against Staph, aureus was in the normal range. Diminished opsonic activity against both E. coli and Staph. aureus was also observed in a patient at an acute stage of systemic lupus erytematosus, and in patients with prolonged EB virus infections. Premature infants, neonates, and children with measles showed a decreased activity against E. coli only. Normal opsonic activity was found in the ascites of a renal failure patient, in a milky ascites, and in the pleural effusion of an osteosarcoma patient. CSF from a suppurative meningites patient showed a higher activity than normal CSF.
日本炎症・再生医学会の論文