<I>Changes of peritoneal mast-cell population in rats with adjuvant arthritis</I>

概要

論文の詳細を見る
Adjuvant was injected into the left hind paw of Sprague-Dawley rats. A marked decrease in the mast-cell count and histamine content of the peritoneal fluid and a significant increase in the histamine content as well as the mast-cell count in the mesentery appeared between 1 and 2 weeks after adjuvant injection. This period approximately coincided with that of the development of secondary inflammatory lesions such as polyarthritis. The effects of some antiinflammatory and immunosuppressive drugs on the decrease in the mast-cell count and histamine content of peritoneal fluid were studied as well as the effect on the development of polyarthritis. With the exception of flufenamic acid, the preventive effects on the decrease in the peritoneal mast-cell count paralleled the prevention of development of arthritic lesions.<BR>These results show that the redistribution of mast cells between the peritoneal cavity and the tissues surrounding it is one of the symptoms of 'adjuvant disease' which results from delayed hypersensitivity.
日本炎症・再生医学会の論文