<I>Thrombophlebitis in Behcet disease</I>
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概要
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Thrombophlebitis of cutaneous vein is frequently recognized, but deep-vein thrombosis (DVT) is rarely detected in Behcet disease.<BR>For the purpose of detection of clinically silent DVT, plethysmography, <SUP>125</SUP>I fibrinogen test and radionuclide venography (RNV) were carried out in patient with Behcet disease.<BR>Pulse bight of the II digits of both feet were siginificantly decreased in Behcet disease compared with healthy controls. <SUP>125</SUP>I fibrinogen test was performed in 10 patients who had clinical manifestations of thrombophlebitis. Increased uptake percentage of <SUP>125</SUP>I fibrinogen was shown in 2 patients, but they seemed to be fals-positive findings.<BR>RNV with simultaneous lung scanning using <SUP>99m</SUP>Tc-macroaggregated albmin (MAA) was performed in 15 patients. Thirteen radionuclide venograms showed presence of DVT. Eight of 13 (62%) patients with DVT had abnormalities in perfusion of their lungs without any changes in the chest X-ray picture.<BR>These results suggested that DVT exsisted in high frequency and RNV was a reliable test for detection of DVT in patients with Behcet disease who had clinical manifestations of thrombophlebitis.<BR>Studies on blood coagulation and fibrinolysis were perfomed on 45 occasions in 21 patiens with Behcet disease. Plasma evels of anti-thrombin III and a2 plasmin inhibitor were significantly lower than in normal controls.<BR>These results suggested that the patients with Behcet disease might be in a state resembling disseminated intravascular coagulation.
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