The binding activity of recombinant human interferon alpha-2a to its receptor on FL cells.
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概要
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The binding activity of purified and 125I-labeled recombinant human interferon alpha-2a (rIFN alfa-2a) to FL cells was studied. The number of receptors per cell and the binding constant were estimated as 1.7×103 and 9.1×1010 M-1, respectively. These values are similar to those reported for natural human interferon alpha (nIFN alfa) and for recombinant human interferon alpha-2b. Unlabeled rIFN alfa-2a and unlabeled nIFN alfa produced in human leukocytes inhibited the binding of 125I-labeled rIFN alfa-2a to a similar degree.These results suggest that rIFN alfa-2a binds to the same cell-receptors as those for nIFN alfa, and that the binding activities of the two are similar.
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日本ウイルス学会 | 論文
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