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In 1977 to 1978 winter, mixed epidemic was observed in Kyushu district with H3N2 and H1N1 subtypes of influenza virus. Fourteen strains of influenza virus were isolated from an outbreak in the pediatric ward of a hospital. Hemagglutination with 13 strains was inhibited by anti-A/FM/1/47 (H1N1) serum but not by anti-A/Kumamoto/22/76 (H3N2) and by anti-A/Tokyo/1/77 (H3N2) sera, suggesting H1 subtype. However, hemagglutinin from one strain (MF/11) was inhibited neither by H1 nor H3 subtype serum. Acute serum from the case from which MF/11 strain was isolated showed negative HI to both H1 and H3 antigens. His convalescent serum showed significant rise in HI against both H1 and H3 antigens. An immune mouse serum against MF/11 strain strongly reacted with both H1 and H3 antigens in HI. MF/11 immune serum neutralize A/Tokyo/1/77 virus in high titer, and neutralize A/USSR/92/77 in lower extent. Above findings suggested coexistence of H3 and H1 antigens in MF/11 strain. Sixty four clones were obtained from plaques on MDCK monolayer inoculated with MF/11 strain at 3rd egg passage. Among 64 clones, 60 was identified as H3 and remained 4 as H1 in HI tests. Further in neuraminidase-inhibition tests carried out in 16 clones, 7 clones were identified as H3N2 and 2 were as H1N1. Remained 7 clones were finally determined as recombinants, 6 having H3N1 and 1 having H1N2 characters. Whether those recombinants were produced in man or in eggs during 3 passages is remained unknown.
- 日本ウイルス学会の論文
日本ウイルス学会 | 論文
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