STUDIES ON THE PRODUCTION OF A VIRAL GROWTH ENHANCING FACTOR (ENHANCER) AND INTERFERON IN EGGS INFECTED WITH INFLUENZA VIRUS A AND ON THE INTERACTION BETWEEN THEM
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概要
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A Viral growth enhancing factor (enhancer) was produced in the chorioallantoic membranes of eggs infected with influenza virus (PR8) and was released into the allantoic fluids. Enhancer was detected by its activity to enhance HA production by HVJ in roller tube cultures of shell-membrane pieces. The enhancement of HA production was obtained either by preincubation of the cultures with enhancer at 37°C for 24hours before challenge of HVJ, or by its addition into the cultures simultaneously with challenge.The production and release of enhancer occurred in the early stages of infection with PR8 virus, Enhancer activity of the allantoic fluid and chorioallantoic membranes declined rapidly after 24hours of infection and was followed by the appearance of interferon activity. The time when enhancer activity was increasing and maintained a high level corresponds with the time when virus was growing approximately at a linear slope. Interferon activity first appeared in the chorioallantoic membranes and allantoic fluids at 36hours after infection with PR8 virus, when virus growth had reached a maximal level. Subsequent rise in interferon titers was associated with decline of cellular virus titers.Interferon blocked enhancer activity when added to cultures of shell-membrane pieces before or after the enhancer, as well as when added at the same time as enhancer. Alternatively, enhancer blocked to some extent interferon activity when added before or after the interferon, as well as when added at the same time as interferon.
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