AN OUTBREAK OF ASEPTIC MENINGITIS DUE TO ECHOVIRUS TYPE 4 IN WAKINOSAWA VILLAGE, AOMORI PREFECTURE, 1964:VIROLOGICAL AND SEROLOGICAL STUDIES

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An outbreak including aseptic meningitis and acute febrile illness took place in a small village; Wakinosawa, Aomori Prefecture of Northern Japan, between June and August of 1964. Virological and serological studies revealed that the epidemic was caused by Echovirus type 4. Echovirus types 4 was isolated from 7 (16%) of 43 cerebrospinal fluids, 16 (35%) of 46 throat swabs and 41 (43%) of 95 faeces obtained from the patients in acute stage within 6 days after onset. Paired sera of 23 patients, 18 with aseptic meningitis and 5 with acute febrile illness, were examined for heutralizing antibody against the Du Toit strain of Echovirus type 4. In all of them, a significant rise of antibody titer was shown. However, neutralizing antibody titer obtained with the current strain (W-45-64) was much lower than that with the Du Toit strain.Outbreaks due to Echovirus type 4 has been reported in many regions of Japan in the summer and fall of 1964 (HINUMA and OHI: Igaku no Ayumi, 51, 498, 1964) and the outbreak reported here is considered to be comprised in the wide-spread occurrence.
日本ウイルス学会の論文