BIOCHEMICAL STUDIES ON THE REPRODUCTION OF BACTERIOPHAGE:(III) EFFECT OF CHLORAMPHENICOL ON RIBONUCLEIC ACID SYNTHESIS INDUCED BY BACTERIOPHAGE INFECTION
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It was found that chloramphenicol, when added before T2 infection, blocked the formation of protein and DNA, but not the RNA synthesis after infection. The RNA synthesis after infection seems to be slightly stimulated by the addition of chloramphenicol. This RNA, which is formed without a priori formation of protein after T2 infection, is also characteristic of T2 infection in its mononucleotide composition. These results show that T2 infection induces a synthesis of new RNA, or at least a specific change in RNA metabolism at first without the prior synthesis of new protein.
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