ETIOLOGY OF EPIDEMIC KERATOCONJUNCTIVITIS. A REVIEW OF THE LITERATURE

概要

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This is a review of the literature on the etiology of epidemic keratoconjunctivitis (EKC). Adenovirus type 8 was first isolated by Jawetz and others from a case of EKC. They demonstrated that in majority of EKC cases, specific neutralization antibodies to this virus can be demonstrated while they are uncommon in normal controls. They also demonstrated that a striking rise of this antibibody occurs in the convalescent serum of this disease. The second strain of this virus was isolated by Chang in Saudi-Arabia from a probale infantile from of EKC, and the third strain by Mitsui and Jawetz in Kumamoto from a case of EKC. Five human volunteers were inoculated by Mitsui with the strain isolated by Jawetz. Four of the five showed a "take". The findings were typical of EKC in three of the positive four and the findings in the last one were also not contradictory. In all of the four cases, there occured a striking rise in the specific neutralizing antibody to this virus, and re-isolation of the virus was succesful on two cases. In a fifth volunteer the inoculation was negative. A significant neutralizing antibody titer was demonstrated in the serum of this cases obtained before the inoculation. All of these results indicate that the etiological role of adenovirus type 8 in EKC is highly possible.
日本ウイルス学会の論文