STUDIES ON VACCINIA HEMAGGLUTININ:4. ON THE EFFECT OF NITROGEN MUSTARDS ON VACCINIA HEMAGGLUTININ AND INFECTIVITY
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概要
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Five nitrogen mustards; methyl bis (beta-chloroethyl) amine hydrochloride, tris (beta-chloroethyl) amine hydrochloride, amyl-bis (beta-chloroethyl) amine hydrochloride, diethyl (beta-chloroethyl) amine hydrochloride and N, N'-tetrakis (beta-chloroethyl) ethylen diamine hydrochloride, and N-oxide of each (N, N'-dioxide with the last amine) were examined in vitro concerning VH or virus inactivating effect (The compounds are referred to only by their initial letters. and vaccinia hemagglutinin is referred to as VH.).Tetrakis was found to be the most effective in inactivating vaccinia hemagglutinin, whereas diethyl. ox was scarcely effective even at the concentration of 1/25 M. VH inactivating activity appeared to depend on the number of betachloroethyl radicals and the N-oxide of each compound was in general less effectiev than the original compound with the exception of tris and its N-oxide. Amyl, which has the same structure as bis except that the former has an amyl-radical in place of methyl-radical in the latter, was far more effective than the latter. A gross parallelism was observed between the VH (inactivating effect) and viral infectivity inactivating effect of the compounds, but diethyl and diethl. ox were effective in inactivating viral infectivity in vitro at the concentration (where VH was hardly inactivated).The order of the compounds in regard to VH inactivating activity will be described as follows: tetrakis>amyl>tris. ox>tetrakis. ox>amyl. ox>tris>bis>bis. ox>diethyl>diethyl. ox.The effect of potassium periodide, hydrogen peroxide or Fenton's reagent on VH was also examined and it was proved that VH was inactivated by potassium periodide, whereas hydrogen perioxide or Fenton's reagent was ineffective under the same conditions.
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