ON THE EXPERIENCES IN LABORATORY DIAGNOSIS OF INFLUENZA AND MUMPS VIRUS INFECTIONS

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Studies were made on the laboratory diagnosis of influenza and mumps, and the following results were obtained:1) Serological diagnosis of influenza was made by hemagglutination inhibition test. There was observed a considerable difference in the antigenic specificity of each influenza strain, and so, it is always necessary to isolate viruses in each influenza epidemic.2) Serological examination of mumps was also carried out by the hemagglutination inhibition tests. Mumps virus combined with its antibody extremely slowly as compared with the influenza viruses: It is necessary, therefore, that before adding to the suspension of red cells, the mixture of antigen and antiserum must be kept at 4°C overnight or at 37°C for one hour.3) Hemagglutination inhibition test and complement fixation test were made on 18 pairs of acute and convalescent sera of mumps patients. Four folds or greater hemagglutinin titer was observed on 88.8 per cent of them. Furthermore was observed remarkable correlation of antibody titers between hemagglutination inhibition test and complement-fixation test.4) The hemagglutination inhibition test and the complement-fixation test were performed several times on the sera of 4 mumps cases during the period of one year. Same tests were made on 158 samples of sera obtained from mumps cases. It was found that the presence of complement-fixation antibodies indicates the recent infection of mumps.5) As an antigen for complement-fixation test, V-antigen (virus-bound antigen) and S-antigen (soluble-chorioallantoic membrane antigen) were used. However, it was not observed that S-antibody did considerably faster decrease than V-antibody from the blood stream, as reported by Henle and others.
日本ウイルス学会の論文

ON THE EXPERIENCES IN LABORATORY DIAGNOSIS OF INFLUENZA AND MUMPS VIRUS INFECTIONS

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日本ウイルス学会 | 論文

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