Peripheral neuropathy and myopathy in long-term hemodialysis patients

概要

論文の詳細を見る
Clinical, blood biochemical, electrophysiological and pathological studies were done for both uremic peripheral neuropathy and uremic myopathy in 25 long-term hemodialysis patients, and the results were compared with 30 patients on conservative therapy. The mean period of hemodialysis was three yearsand three months. Ccr in the conservative therapy group was 4.1±0.4 (mean±SE) m<I>l</I>/min. Of the 25 hemodialysis patients, neurogenic changes were recognized in all 25 (100%) and myogenic changes in six (24%). Of the30 patients on conservative therapy, neurogenic changes were seen in 19 (63%) and myogenic changes in 13 (43%). Four (13%) showed no abnormalities. Mixed changes were seen in both groups. Maximum motor nerve conduction velocity and maximum sensory nerve conduction velocity were more frequently slowed and showed significantly (p<0.001-p<0.02) lower values in the dialysis group compared with those on conservative therapy. Consequently, the two groups exhibited no significant differences in myopathy, whereas peripheral neuropathy was more frequent and more severe in the dialysis group. Accordingly, improvement in or disappearance of peripheral neuropathy cannot be expected with standard hemodialysis.
社団法人日本透析医学会の論文