EFFECT OF MINOR HISTOCOMPATIBILITY ANTIGEN INCOMPATIBILITIES IN ALLOGENEIC STEM CELL TRANSPLANTATION FROM HLA-IDENTICAL DONORS
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概要
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Mismatches of minor histocompatibility antigens (mHas) between HLA-identical stem cell donors and recipients are known as a major risk factor for graft-versus-host disease (GVHD). We determined alleles of 9mHas for 40 patients who had undergone stem cell transplantation from HLA-identical donors and investigated the association of their mismatches with relapse rate and GVHD. We observed a tendency toward a higher incidence of GVHD and lower relapse rate in patients with at least one or more incompatibilities of mHas than in patients without incompatibilities. In particular, relapse rate was significantly lower in a group of patients grafted from HLA-identical sibling donors with mHa-incompatibilities (p=0.05). In addition, no relapse was observed in at least one or more mHa-incompatible patients who developed GVHD. We conclude that mHas contribute to the development of the graft-versus-leukemia effect and may potentiate the graft-versus-leukemia effect in incompatible patients who develop GVHD.
- 一般社団法人 日本輸血・細胞治療学会の論文
一般社団法人 日本輸血・細胞治療学会 | 論文
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