Purine metabolic enzymes in sera of healthy HTLV-1 carriers.
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概要
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The purine metabolic enzymes; adenosine deaminase (ADA) and purine nucleoside phosphorylase (PNP) are known to be associated with lymphocyte differentiation. ADA isoenzyme (ADA1 and ADA2) and PNP activities were assayed in the sera of 22 healthy carriers with positive for anti-HTLV-1 antibody and 20 normal individuals. The results revealed that both ADA2 and PNP activities were significantly elevated in sera of healthy carriers (p<0.001) as compared with normal controls. No significant difference in ADA1 activity was noted in the two groups. These data imply that ADA2 serum level is more likely to reflect the condition of peripheral T lymphocytes than that of total ADA activity. Measurement of these enzyme activities in serum may be a useful parameter of diagnosis in human T-cell leukemia/lymphoma virus-1 infection.
- 一般社団法人 日本輸血・細胞治療学会の論文
一般社団法人 日本輸血・細胞治療学会 | 論文
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