The Synergistic Effect of Suplatast Tosilate and Tacrolimus Hydrate Ointment on the "Red Face" of Adult-type Atopic Dermatitis
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We compared the effect of topical tacrolimus hydrate ointment alone with the combination therapy of topical tacrolimus hydrate ointment plus oral suplatast tosilate administration on the "red face" seen in adult-type atopic dermatitis patients for ten weeks. The parameters to measure their effects were the severity of the skin inflammation, the number of eosinophils, serum IgE level and the weekly dosage of topical tacrolimus hydrate ointment. In result, there was no significant difference between those two groups concerning the former three parameters. However, the weekly dosage of topical tacrolimus hydrate ointment was much more decreased in the patients treated with the combination therapy (average: from 2.0g/week to 0.4g/week) compared with the patients treated with topical tacrolimus hydrate ointment alone (from 2.3g/week to 1.2g/week). Moreover, seven (46.7%) out of 15 patients treated with the combination therapy could stop the daily use of tacrolimus hydrate ointment, whereas only two (18.2%) out of ll patients treated with topical tacrolimus hydrate ointment alone could stop. These results suggest that the combination therapy of topical tacrolimus hydrate ointment plusoral suplatast tosilate administration would reduce the dosage of tacrolimus hydrate ointment required to control the "red face" seen in adult-type atopic dermatitis patients, and thus reducing the complication of skin infectious diseases such as Kaposi's varicelliform eruption and folliculitis
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