Drug Eruption Caused by Docetaxel.
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概要
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A toxic eruption was noticed in 4 cases of 6 patients with recurrent or advanced breastcancer, who were given intra-arterial one shot infusion treatment in the subclavian arteryof varying dose of Docetaxel (Taxoteres<SUP>R</SUP>) (80mg-100mg/body), from May 1998 to March1999. Its onset was 2days after the second administration in the earliest case and 2 daysfollowing the 4th course in the latest. Three cases developed toxic eruption by administrationinterval of 10-13days. The types of skin lesion observed were erythema, erosion, bulla and ulcer in the region coinciding with a distribution of the artery used. No case developedtoxic eruption by an intra-venous administration of the drug. So, we consideredthe toxic eruption as the direct tissue injury due to high concentration of anti-cancer product.<BR>Skin Research, 41: 542-546, 1999
- 日本皮膚科学会大阪地方会の論文
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