Laboratory Findings of Patients with Drug Eruptions; Changes of Data before and after Provocative Test.
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概要
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The abnormalities of laboratory studies due to drug eruptions are discussed. We enrolled 138 patients with drug eruption diagnosed by provocative test at Sakai Municipal Hospital since 1989 to 1994. The elevation of serum LDH and CRP level occurred in 45% and 34% of patients, respectively. Hematological studies revealed moderate eosinophilia in 37% of patients. The studies revealed few abnormalities of renal or liver function. More cases of abnormalities occurred in patients with drug eruptions of erythema multiforme, exanthematic and exfoliative dermatitis type. Urticaria type drug eruption showed no abnormalities. The changes of laboratory data between before and after provocative test were analyzed on the patients with drug eruptions of erythema multiforme, exanthematic, exfoliative dermatitis and lichenoid eruption type. The count and percentage of neutrophils were significantly elevated (P value: 0.01) within 24 hours. White blood cell count revealed slight elevation. LDH and eosinophil showed no change.
- 日本皮膚科学会大阪地方会の論文
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