Serum Type IV Collagen and Laminin Levels in Scleroderma. Relation to Internal Involvements of Systemic Scleroderma(PSS) and Analyses of 7 PSS Cases with Elevated Values.:Relation to Internal Involvements of Systemic Scleroderma (PSS) and Analyses of 7 PS
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Serum type IV collagen 7S and laminin P1 levels were measured in 33 patients with systemic scleroderma (PSS), 6 with localized scleroderma and one with mixed connective tissue disease. The patients who had esophageal and lung involvements showed significantly higher (p<0.05) laminin values than those who had esophageal dysfunction only or who had neither of t hem . Both values were elevated together over mean+2SD (standard deviation) in 7 PSS (six Barnett type 3 and one type 2) patients, out of whom all had esophageal dysfunction and 5 had lung fibrosis. The 7 cases all appeared to be typical or severe as PSS. Our results suggest that these values serve as serum parameters of PSS.
- 日本皮膚科学会大阪地方会の論文
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