Skin Safety of the New Antifungal Agent MT-861. A Comparison with Commercial Products.:A Comparison with Commercial Products
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概要
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The skin safety of 0.5% and 1.0% creams of the new antifungal agent MT-861 (amorolfine hydrochloride), provided by Kyorin Pharmaceutical Co., Ltd., was investigated in a patch test with 29 healthy persons as subjects, using 1% clotrimazole cream, 1% econazole nitrate cream and 1 % bifonazole cream as control drugs. A positive response in the patch test was noted in only 1 case each of 1% MT-861 cream and 1% econazole nitrate cream, while the response to the other drugs was less than (±). The skin irritation indices were all below the allowable index of 15.0, with indices of 6.9 for 1 % MT-861 cream, 12.1 for 1 % econazole nitrate cream (which was slightly higher), and 1.7 for 0.5% MT-861 cream, suggesting that MT-861 is a drug of equally low irritation as 1% clotrimazole cream and 1% bifonazole cream.
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