Drug induced-lichen planus. Statistical and immunohistological studies.:Statistical and Immunohistological Studies
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Statistical studies were performed on 16patients seen for last 10 years with druginduced-lichen planus. All patients had receivedseveral kinds of drugs, especially vasodilatorsor diuretics. Of these, 9 patients had receivedcinnarizine. The time lags between onset ofdrug-therapy and development of rash werevarying between 2 and 12 months. Theseeruptions persisted for about 2 months afterdrug withdrowal. Patch tests were performedwith 20 probably causative drugs on 7 patients, however, no positive reactions were recognized. We studied 4 patients immunohistologicallyusing an immunoperoxidase technique and adirect immunofluorescent technique. In allsamples, the majority of infiltrating cells werespecifically labelled by CD3, CD4, and CD8 antibodies, and furthermore, a large percentageof these cells expressed the HLA-DR antigens. Some infiltrating cells reacted with anti-IL-2receptor antibodies (CD25). In 3 of 4 patients, epidermal intercellular staining with HLA-DRantibodies was observed.
- 日本皮膚科学会大阪地方会の論文
日本皮膚科学会大阪地方会 | 論文
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