Strain difference in the development of preimplantation mouse embryos in a medium supplemented with superoxide dismutase or ethylenediamine tetraacetic acid

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Effects of superoxide dismutase (SOD, from bovine erythrocytes) or ethylenediamine tetraacetic acid (EDTA-2Na) on the preimplantation development of mouse embryos obtained by fertilization in vitro were examined in different strains. In"the partially blocking strains"(ICR and DDD) in which small proportions of in vitro fertilized embryos develop beyond the 2-cell stage in Whitten's medium, both SOD and EDTA exerted significant effects in promoting the development to the 4-cell and to the blastocyst stage. In"the completely blocking strain"(AKR) in which none of the embryos develop beyond the 2-cell stage, neither SOD nor EDTA was effective in overcoming the 2-cell block. A significant paternal effect was observed when the development of DDDxDDD embryos was compared with that of DDDxC57BL embryos. It is suggested that both SOD and EDTA may share a common mechanism in promoting the embryonic development in vitro.
日本哺乳動物卵子学会の論文