Inhibitory effect of monoclonal antibodies to porcine zona pellucida antigen cross-reactive to humans on in vitro fertilization systems
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概要
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Anti-fertility effect of three monoclonal antibodies (3A4-2G1, 1D5-2B7, 1F2-1B8) produced to porcine zona pellucida (PZP) antigens crossreactive to humans was studied by using in vitro fertilization system of porcine and human eggs. Polyclonal mouse antiserum to PZP had a strong inhibitory effect on both porcine and human eggs. However, only two monoclonal antibodies (3A4-2G1, 1D5-2B7) on porcine eggs and no monoclonal antibodies on human eggs did show the inhibitory effect. When the monoclonal antibody-treated human eggs were further treated with anti mouse y-globulin serum as a second antibody, two of the three monoclonal antibodies (3A4-2G1, 1D5-2B7) showed an inhibitory effect on sperm binding and penetration to ZP of human eggs. These results suggest that the antigen epitopes corresponding to the monoclonal antibodies with anti-fertility activity might be located densely or close to the sperm receptors on ZP of porcine and human eggs.
- 日本哺乳動物卵子学会の論文
日本哺乳動物卵子学会 | 論文
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