Synthesis of Core-Shell Type Gel by Thermal Acid-Catalyzed Deesterification of Poly (t-butyl methacrylate) Gel.

概要

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Cylindrical poly (<I>t</I>-butyl methacrylate) gels (GBM) and GBM with a small amount of methacrylic acid unit were prepared. When GBM with <I>p</I>-toluenesulfonic acid as an acid catalyst was placed in a heated alkyl acetate, which works as an acid acceptor, it started to swell from the outer surface and to deesterify at the same time. At the end of the reaction, the gel was divided into a swollen shell layer, which had been hardly deesterified, and an unswollen core part, which had been deesterified. The final core size was controlled by the diffusion rate of the solvent and deesterification rate. Accordingly, the core size depended on many factors such as acid concentration in GBM, reaction temperature, concentration and bulkiness of acid acceptor. When the gel capsule aged at 120°C for 1 h was used, the aged shell layer served as a permeation barrier for many chemicals including water. This suggests that the gel capsule obtained is useful for a drug carrier.
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