Spectrofluorophotometric Determination of Quinidine Sulfate in Equine Plasma After Oral Administration

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Spectrofluorophotometric determination of quinidine sulfate in horse plasma was established, using deproteinization with 20 % metaphosphoric acid. The plasma levels of quinidine sulfate after a single oral administration with 40 or 60 mg/kg were determined. A peak value of 10 pg/ml was found 3 hours after administration with 60 mg/kg. The substance was detectable even 30 hours after administration. A single oral dose of 40 mg/kg showed no significant side effects, but one of 60 mg/kg induced colic or uterine pain in one horse as side effects.
日本ウマ科学会の論文